Publications by authors named "A Tuunainen"
Objective: Patients with atypical anorexia nervosa (AN) are often in the normal-weight range at presentation; however, signs of starvation and medical instability are not rare. White matter (WM) microstructural correlates of atypical AN have not yet been investigated, leaving an important gap in our knowledge regarding the neural pathogenesis of this disorder.
Method: We investigated WM microstructural integrity in 25 drug-naïve adolescent patients with atypical AN and 25 healthy controls, using diffusion tensor imaging (DTI) with a tract-based spatial statistics (TBSS) approach.
Atypical anorexia nervosa (AN) has a high incidence in adolescents and can result in significant morbidity and mortality. Neuroimaging could improve our knowledge regarding the pathogenesis of eating disorders (EDs), however research on adolescents with EDs is limited. To date no neuroimaging studies have been conducted to investigate brain functional connectivity in atypical AN.
View Article and Find Full Text PDFArticle Synopsis
- Generalized anxiety disorder (GAD) is common in adolescents, and early detection could help prevent serious mental health issues later on.
- The study examined the relationship between epigenetic changes (specifically DNA methylation) in blood and the likelihood of developing GAD in 221 healthy adolescents, finding one significant methylation site linked to higher risk.
- The identified CpG site (cg16333992) is related to the STK32B gene, which plays a role in stress responses, suggesting that DNA methylation can indicate potential anxiety risk in young people.
WITHDRAWN: Risperidone versus other atypical antipsychotic medication for schizophrenia.
Cochrane Database Syst Rev
September 2016
Background: Risperidone is one of a number of 'atypical antipsychotics' which are currently being marketed for the treatment of those with schizophrenia, largely on the basis of claims of improved tolerability and effectiveness compared to much cheaper conventional antipsychotics. The efficacy of risperidone has already been compared to conventional drugs, but it remains unclear how risperidone compares with other atypical antipsychotic drugs such as clozapine.
Objectives: To determine the effects of risperidone compared with other atypical antipsychotic drugs for schizophrenia.
Insomnia symptoms must be differentiated from insomnia disorder. The correct aiagnosis or insomnia aisoraer is important, as insomnia may also be a symptom of many other diseases. Cognitive behavioral methods are recommended as first-line treatment options.
View Article and Find Full Text PDF