Publications by authors named "A Turki"
Background/objectives: The COVID-19 pandemic underscored the urgent need for rapid, efficient testing methods at large-scale events to control virus spread. This study leverages queueing theory to explore how different floor plan configurations affect the efficiency of Rapid Antigen Diagnostic Test (RADT) centers at mass gatherings, aiming to enhance throughput and minimize wait times.
Methods: Employing the model (Markovian Arrival Process/phase-type service distribution with c servers), this study compared the operational efficiency of RADT centers using U-shaped and straight-line floor plans.
The treatment landscape for lymphoma and multiple myeloma, which disproportionally affect older adults, has been transformed by the advent of T cell-mediated immunotherapies, including immune checkpoint inhibition, T cell-engaging bispecific antibodies, and chimeric antigen receptor (CAR) T cell therapy, during the last decade. These treatment modalities re-enable the patient's own immune system to combat malignant cells and offer the potential for sustained remissions and cure for various diseases.Age profoundly affects the physiological function of the immune system.
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- Acquired resistance to cisplatin, a common treatment for ovarian cancer, presents significant challenges in therapy effectiveness, leading researchers to identify a new phenomenon in cancer cell behavior.
- This study introduces the concept of epithelial-mesenchymal-ectodermal transition (EMET), which describes how ovarian cancer cells undergo a transformation that includes characteristics of neuronal differentiation and stemness, indicating a shift in their cellular identity.
- The researchers also found that a small population of these cancer cells, which exhibit both neuronal-like features and multidrug resistance, likely originate from neural cells, suggesting that ovarian cancer may arise from a neuroepithelial lineage.
Article Synopsis
- Since 2017, combining targeted therapies with traditional chemotherapy has led to better outcomes for acute myeloid leukemia (AML) patients.
- A study of 5,359 AML patients over 20 years used data from the HARMONY Alliance to analyze treatment outcomes during four 5-year periods from 1997 to 2016.
- Results show significant improvements in 5-year survival rates and reduced 60-day mortality (from 13.0% to 4.7%), even across different genetic risk groups, indicating that the advancements in treatment have positively affected patient outcomes.
Article Synopsis
- - Tamarix tetragyna, a plant found in the Mediterranean and some Arab regions, has several medicinal properties, which this study aims to investigate through its leaf and stem extracts.
- - The study analyzed the phytochemical composition using gas chromatography-mass spectrometry and tested the extracts' cytotoxicity against cancer cell lines (MCF-7, HepG-2, HCT-116, and A-549) using the MTT assay and apoptosis methods.
- - Results showed that the plant extracts exhibited significant cytotoxic activity, especially against A-549 cells, with specific bioactive compounds identified that could lead to further research for potential anticancer therapies.