Publications by authors named "A Turcas"
Background: Craniospinal irradiation (CSI) is a complex radiotherapy (RT) technique required for treating specific brain tumors and some hematologic malignancies. With large volumes of hematogenous bone marrow (BM) being irradiated, CSI could cause acute hematologic toxicity, leading to treatment interruptions or severe complications. We report on the dynamics and dose/volume predictors of hematologic toxicity during CSI.
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- In prepubertal patients, uneven irradiation of the spine can cause growth-related issues like kyphoscoliosis later in life.
- A study reviewed 101 pediatric cases from QUARTET-affiliated trials, focusing on vertebral delineation and dosimetry.
- Despite existing guidelines, the study found significant variability in how vertebrae were outlined, which affected the dosimetry results.
Article Synopsis
- This study evaluates a deep-learning, MRI-based auto-contouring tool aimed at improving the speed and accuracy of delineating brain organs at risk during radiotherapy, compared to manual methods.
- The research involved analyzing data from thirty patients, where both AI-generated contours and manually corrected contours were compared using various accuracy metrics like Dice Similarity Coefficient and mean surface distance.
- Results indicated that auto-contouring was significantly faster than manual contouring, with good accuracy for larger structures; however, improvements are needed for smaller structures to enhance overall effectiveness in clinical practice.
Background And Purpose: SIOP Europe's QUARTET project launched in 2016; aiming to improve access to high-quality radiotherapy for children and adolescents treated within clinical trials across Europe. The aim of this report is to present the profile of institutions participating in six QUARTET-affiliated trials and a description of the initial individual case review (ICR) outcomes.
Methods: This is a two-part analysis.