Publications by authors named "A Tsubota"
Frailty and fractures are closely associated with adverse clinical outcomes. This retrospective study investigated the prognostic impact of frailty, prevalent fractures, and the coexistence of both in patients with cirrhosis. Frailty was defined according to the Fried frailty phenotype criteria: weight loss, weakness, exhaustion, slowness, and low physical activity.
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- Sarcopenia and osteoporosis negatively affect patients with chronic liver disease (CLD), and this study compares two methods for assessing muscle mass: bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DXA).
- The study included 173 patients and found strong correlation and agreement between ASMI values obtained from BIA and DXA for diagnosing sarcopenia and osteosarcopenia.
- It concludes that DXA is a valuable tool for a thorough assessment of muscle and bone health in CLD patients, highlighting the need for effective diagnostics in managing these conditions.
Article Synopsis
- Patients with chronic liver disease (CLD) often experience malnutrition and increased risk of bone diseases, which can lead to worse health outcomes.
- This study included 209 CLD patients and found that those in the "nutrition-related risk" group had a higher prevalence of osteoporosis compared to those without such risk.
- The geriatric nutritional risk index (GNRI) was determined to be a strong predictor for osteoporosis and fracture risk, indicating its potential use as an important tool for managing bone health in these patients.
Aims: To evaluate the efficacy and safety of oral semaglutide for type 2 diabetes mellitus (T2DM) in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).
Materials And Methods: This was a single-arm, multicentre, prospective study. Among 80 consecutive patients with MASLD and T2DM who newly received oral semaglutide, 70 completed 48-week oral semaglutide treatment as scheduled and were included in an efficacy analysis.
Hibernating animals undergo a unique and reversible decrease in their whole-body metabolism, which is often accompanied by a suppression of mitochondrial respiration. However, the precise mechanisms underlying these seasonal shifts in mitochondrial metabolism remain unclear. In this study, the effect of the serum from active and hibernating Japanese black bears on mitochondrial respiration was assessed.
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