Publications by authors named "A Tsimpidakis"

Background: Primary cutaneous B-cell lymphomas (PCBCLs) are rare cutaneous neoplasms with limited literature regarding treatment options and associated treatment outcomes. This study aimed to investigate and present real-world treatment outcomes in patients with PCBCLs.

Methods: All patients with PCBCL who were treated in five major referral centers for cutaneous lymphoma in Greece over 10 years were retrospectively included with their baseline characteristics and treatment-associated outcomes collected and analyzed.

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Article Synopsis
  • - The study analyzed the effectiveness and safety of methotrexate (MTX) in treating mycosis fungoides (MF) across different stages, involving 211 patients from five Greek centers, with a median age of 68.3 years.
  • - Results showed an overall response rate of 55.5%, with better outcomes in patients receiving MTX as a first-line treatment and those with erythrodermic disease compared to tumor stage disease.
  • - The study concludes that MTX is a viable first-line treatment option for MF, demonstrating varying progression-free survival rates depending on the disease stage and acceptable safety profiles.
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Introduction: Data regarding quality of life (QoL) of oncologic patients experiencing dermatologic immune-related adverse events (dirAEs) and their course after dermatologic intervention are scarce.

Objectives: To assess the impact of dirAEs on patients QoL and to investigate the correlation between dermatologic and oncologic indexes used for estimating QoL.

Methods: We enrolled oncologic patients with dirAEs managed in two supportive onco-dermatology outpatient clinics in Greece.

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We present a case of a 75-year-old male patient who experienced a severe exacerbation of his Kaposi sarcoma lesions, which have remained clinically stable for a year, following treatment with BRAF/mitogen-activated protein kinase inhibitors for his coexisting melanoma. In this case, we present the possibility that BRAF/MEK inhibition may be mechanistically associated with the progression of Kaposi sarcoma and briefly discuss the potential mechanisms behind this phenomenon.

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