Limited role for intratubal methotrexate treatment of ectopic pregnancy.

Objective: To test the effectiveness of laparoscopic intratubal methotrexate (MTX) injection or salpingostomy in the treatment of ectopic pregnancy (EP).

Design: Prospective predefined protocol.

Setting: Department of Obstetrics and Gynecology of a university-affiliated hospital.

Spontaneous resolution of ectopic tubal pregnancy: natural history.

Objective: To determine the characteristics and long-term outcome of women succeeding or failing expectant management of ectopic pregnancy (EP).

Design: Prospective, defined protocol.

Setting: University-affiliated gynecology department.

Laparoscopic management of adnexal cystic masses in postmenopausal women.

Objective: To evaluate laparoscopic treatment of postmenopausal women with an adnexal cystic mass predicted to be benign.

Methods: Selection criteria were transvaginal sonographic appearance other than a complex cyst and a normal serum CA 125 level. During the period May 1988 to June 1993, 55 women fulfilled the criteria and underwent operative laparoscopy.

Pharmacokinetics of methotrexate after local tubal injection for conservative treatment of ectopic pregnancy.

Methotrexate peak level after intratubal injection was found to be significantly lower than the accepted toxic level. After IM injection, MTX peak level and the AUC were found to be similar to the levels observed after intratubal injection. The advantage of tubal injection over IM injection is challenged.

Intracervical administration of prostaglandin E2-gel prior to therapeutic abortion: a prospective randomized double-blind study.

Forty primigravid women due to undergo first trimester termination of pregnancy were randomly selected for intracervical application of 1 mg prostaglandin E2 in gel or gel only as placebo. In the PGE2-gel group, a marked dilatation of the cervical canal was obtained, with post-gel treatment mean Hegar dilatation of 11.18 mm in that group, compared to 4.