Publications by authors named "A Trinquand"
Acute promyelocytic leukaemia (APL), defined by the t(15;17)(q24;q21) translocation, accounts for 5%-10% of paediatric acute myeloid leukaemia cases. All-trans retinoic acid (ATRA) and arsenic trioxide (ATO) are key treatments, though ATO access varies. We evaluated treatment, complications and survival in 50 UK paediatric APL patients diagnosed between 2014 and 2021.
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- * A study of 41 children showed a 43.6% complete remission rate, with most achieving minimal residual disease (MRD) negativity.
- * Venetoclax was effective for bridging patients to transplant, with a 75% success rate, and those starting treatment with MRD <1% had significantly better outcomes in terms of MRD negativity and overall survival.
Background: Constitutional mismatch repair deficiency syndrome (CMMRD) is a rare childhood cancer predisposition syndrome associated with a broad spectrum of malignancies, including non-Hodgkin lymphomas (NHL). Most patients die due to cancer before the age of 20 years. Limited data exist on CMMRD-associated lymphomas and their outcome.
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