Publications by authors named "A Trimaille"
Background And Objectives: Initially described as a benign acute cardiomyopathy, Takotsubo syndrome has been linked to elevated mortality rates. Emerging evidence suggests that unresolved myocardial inflammation may contribute to this adverse prognosis. This study aimed to evaluate the incremental prognostic utility of C-reactive protein (CRP) in conjunction with the InterTAK prognosis score for stratifying long-term mortality in Takotsubo syndrome.
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- The study focused on the use of a machine learning model using initial transthoracic echocardiography (TTE) to predict in-hospital major adverse events (MAEs) in patients admitted to intensive cardiac care units (ICCU).
- A total of 1,499 patients were evaluated, and the model showed significant accuracy, highlighting five key TTE parameters that contributed to its predictions.
- The machine learning model outperformed traditional scoring methods, indicating it could serve as a better tool for risk stratification in heart patients.
Article Synopsis
- - Pathological tissues produce various substances, including extracellular vesicles (EVs) from active or dying cells.
- - EVs found in diseased heart valves may play a significant role in the development of valve thrombosis.
- - In cases of human aortic stenosis, EVs can activate valvular endothelial cells, causing dysfunction and increasing the chances of blood clotting.