Publications by authors named "A Toyota"
After developing job-exposure matrices (JEMs) for screen and sedentary time, we aimed to assess the associations between the JEM-derived exposures and various ocular diseases. We collected data from patients hospitalized from 2005 to 2021. JEMs were developed from 41,718 patients with occupational information and screen and sedentary times.
View Article and Find Full Text PDFArticle Synopsis
- A job-exposure matrix was created to analyze sedentary behavior in relation to non-communicable diseases, using data from over 41,000 individuals.
- The matrix was applied to a large cohort in a case-control study, revealing a connection between higher sedentary time and increased risks of diabetes, heart attacks, and endometrial cancer, while suggesting lower stroke risks.
- The findings emphasize the need to address sedentary behavior in workplace settings due to its significant health implications.
Previously, we reported the new pyrido-pyridazinone template as a feline sarcoma-related (FER) tyrosine kinase inhibitor. Representative compound () showed strong enzyme inhibitory activity (IC50 = 0.5 nM), however, its antitumor effect was insufficient, probably due to poor solubility and resultant low bioavailability (BA).
View Article and Find Full Text PDFPrcis: In this case-control study of the Japanese population, including 3207 glaucoma cases, alcohol consumption patterns such as frequency and quantity showed a positive association with glaucoma prevalence.
Purpose: To examine the association between alcohol consumption patterns and glaucoma.
Subjects And Methods: This case-control study evaluated 3207 cases with glaucoma and 3207 matched controls.
Background: The efficacy of the unified protocol of the transdiagnostic treatment for emotional disorders (UP) has been poorly studied in patients with depressive disorders. This study aimed to examine the efficacy of UP for improving depressive symptoms in patients with depressive and/or anxiety-related disorders.
Methods: This assessor-blinded, randomized, 20-week, parallel-group, superiority study compared the efficacy of the UP with treatment-as-usual (UP-TAU) wait-list with treatment-as-usual (WL-TAU).