Publications by authors named "A Toshitani"

Article Synopsis
  • Patients with atopic dermatitis (AD) have significantly lower levels of secretory IgA (sIgA) in their tears compared to healthy individuals.
  • The study used a nitrocellulose membrane to measure sIgA secretion and found a correlation between lower sIgA and an increased presence of Staphylococcus aureus in the tears of AD patients.
  • These results indicate that reduced sIgA on mucous membranes may contribute to the development of ocular lesions and skin problems associated with AD.
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There is a great need to develop a method for making an accurate and reliable in vitro diagnosis of adverse hypersensitivity reactions to drugs. We measured the amount of sulfidoleukotriene (sLT) released from the peripheral blood leukocytes obtained from 25 patients who developed hypersensitivity reactions following the administration of nonsteroidal anti-inflammatory drugs (NSAIDs); 12 patients demonstrated reactions to Voltaren, 8 patients to Bufferin, and 5 patients to Sedes G. The stimulation index, the ratio of the amounts of sLT (pg/ml) incubated with and without drugs, was considerably higher in the patients than in the controls, which consisted of 5 nonallergic healthy subjects.

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Article Synopsis
  • Two cases of skin lesions were observed that looked like comedones, featuring firm black papules.
  • Histopathological examination revealed these lesions resembled dilated hair follicles with issues related to the hair cortex.
  • The authors suggest that these findings represent a unique variant of a known skin condition, proposing the term "hair cortex comedo" for these lesions.
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The purpose of this study was to assess the possible role of the (R)- and (S)- enantiomers of the phenytoin metabolite p-HPPH in the pathogenesis of gingival hyperplasia (GH). About 98% of circulating p-HPPH is in the (S)-form. There were significant differences between patients with and without GH in (R)-p-HPPH level (0.

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