Publications by authors named "A Tortelli"
Article Synopsis
- Research shows that migrant status and ethnic minority background increase the risk of psychosis, but it's unclear if this also applies to subclinical psychosis.
- In a study with 460 participants, first and second-generation migrants, as well as certain ethnic minorities, reported higher levels of negative psychotic traits compared to a reference population.
- These findings suggest a connection between negative schizotypal traits and migrant/ethnic status, indicating a need for specific mental health interventions to support these groups and prevent the development of psychotic disorders.
Background: The association between cannabis and psychosis is established, but the role of underlying genetics is unclear. We used data from the EU-GEI case-control study and UK Biobank to examine the independent and combined effect of heavy cannabis use and schizophrenia polygenic risk score (PRS) on risk for psychosis.
Methods: Genome-wide association study summary statistics from the Psychiatric Genomics Consortium and the Genomic Psychiatry Cohort were used to calculate schizophrenia and cannabis use disorder (CUD) PRS for 1098 participants from the EU-GEI study and 143600 from the UK Biobank.
Background: Cannabis use and familial vulnerability to psychosis have been associated with social cognition deficits. This study examined the potential relationship between cannabis use and cognitive biases underlying social cognition and functioning in patients with first episode psychosis (FEP), their siblings, and controls.
Methods: We analyzed a sample of 543 participants with FEP, 203 siblings, and 1168 controls from the EU-GEI study using a correlational design.
Article Synopsis
- - The study investigates the link between urban living conditions (urbanicity) and schizotypy, a potential precursor to psychosis, suggesting this relationship varies significantly between North-western and Southern Europe.
- - Researchers assessed 1080 individuals across 14 sites in both regions, measuring urbanicity through local population density and controlling for factors like age and childhood experiences.
- - Findings reveal that higher population density is strongly associated with increased schizotypy in North-western Europe, while the effect is notably weaker in Southern Europe, indicating that urbanization’s impact on mental health is not uniform across different contexts.
Childhood adversity is associated with various clinical dimensions in psychosis; however, how genetic vulnerability shapes the adversity-associated psychopathological signature is yet to be studied. We studied data of 583 First Episode Psychosis (FEP) cases from the EU-GEI FEP case-control study, including Polygenic risk scores for major depressive disorder (MDD-PRS), bipolar disorder (BD-PRS) and schizophrenia (SZ-PRS); childhood adversity measured with the total score of the Childhood Trauma Questionnaire (CTQ); and positive, negative, depressive and manic psychopathological domains from a factor model of transdiagnostic dimensions. Genes and environment interactions were explored as a departure from a multiplicative effect of PRSs and total CTQ on each dimension.
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