Publications by authors named "A Torriglia"
Reconsidering the spectral distribution of light: Do people perceive watts or photons?
Light Res Technol
December 2024
Article Synopsis
- The paper discusses the importance of spectral distribution in non-monochromatic optical radiation, its relevance in research, and its applications in understanding light's interaction with matter, including humans.
- It highlights common misconceptions in the lighting field that lead to incorrect claims, often due to relying on graphical analyses of spectral distribution.
- The authors stress the significance of considering the particle nature of light and advocate for the use of the photon system of units in lighting research to ensure accurate applications of spectral distributions and spectral weighting functions.
Glyburide, a sulfonylurea drug used to treat type 2 diabetes, boasts neuroprotective effects by targeting the sulfonylurea receptor 1 (SUR1) and associated ion channels in various cell types, including those in the central nervous system and the retina. Previously, we demonstrated that glyburide therapy improved retinal function and structure in a rat model of diabetic retinopathy. In the present study, we explore the application of glyburide in non-neovascular ("dry") age-related macular degeneration (AMD), another progressive disease characterized by oxidative stress-induced damage and neuroinflammation that trigger cell death in the retina.
View Article and Find Full Text PDFLight is known to induce retinal damage affecting photoreceptors and retinal pigment epithelium. For polychromatic light, the blue part of the spectrum is thought to be the only responsible for photochemical damage, leading to the establishment of a phototoxicity threshold for blue light (445 nm). For humans it corresponds to a retinal dose of 22 J/cm.
View Article and Find Full Text PDFBackground: Nowadays artificial light highly increases human exposure to light leading to circadian rhythm and sleep perturbations. Moreover, excessive exposure of ocular structures to photons can induce irreversible retinal damage. Meta-analyses showed that sunlight exposure influences the age of onset and the progression of Age-related macular degeneration (AMD), the leading cause of blindness in people over fifty-year old.
View Article and Find Full Text PDFEffectiveness and safety of implantable loop recorder and clinical utility of remote monitoring in patients with unexplained, recurrent, traumatic syncope.
Expert Rev Med Devices
January 2023
Background: Implantable loop recorder (ILR) is still underutilized in clinical practice, especially in the setting of elderly patients with recurrent, traumatic, unexplained syncope. Data on the actual risk of traumatic syncopal recurrence during ILR monitoring in this specific patient setting are lacking.
Research Design And Methods: Prospective, multicentre registry enrolling consecutive patients undergoing ILR insertion for unexplained, recurrent, traumatic syncope.