Fusion Gene Transcript as Measurable Residual Disease Marker in Multiple Myeloma.

Multiple myeloma (MM) is the second most common hematological malignancy. Approximately 15% of MM patients are affected by the t(4;14) translocation resulting in the fusion transcript. Breakage occurs in three major breakpoint regions within the gene (MB4-1, MB4-2, and MB4-3), where MB4-1 leads to the production of full-length protein, while truncated proteins are expressed in the other two cases.

[Calreticulin: Pathophysiology of an unusual gain-of-function and its clinical consequences].

One characteristic type of the common somatic mutations causing myeloproliferative neoplasias is the frameshift mutation of the calreticulin gene that leads to proteins of abnormal structure. The pathologic protein induces novel cell biological processes that are fundamental to the onset and maintenance of myeloproliferative diseases. In this review, an insight is provided into these processes, aiding better understanding of the underlining pathobiological processes and eventually to more effective therapy in the future.

Lessons and Best Practices for Physical Therapy in Brigade Combat Team Operations.

Physical therapists (PT) have an integral role in supporting readiness of the Army warfighter. With an increased demand for active duty PTs and the transition to Defense Health Agency (DHA), more direct commission PTs and new graduates as first lieutenants will see themselves positioned in brigade combat teams (BCT). Traditionally, this role is given to a captain due to experience.

Congenital syphilis as a cause of death in a newborn in 31st week of pregnancy - significance of testing for syphilis during pregnancy.

Objective: Description of a case of newborn death after acute caesarean section in 31st week of pregnancy because of mothers syphilitic infection.

Results: Fifteen-years-old primigravid woman in 31st week of pregnancy was admitted to a secondary level hospital due to a high risk of preterm labor. The pregnancy was terminated with an acute caesarean section because of pathological cardiotocograph record.

Thrombotic microangiopathy and pregnancy.

Objective: The aim of this study is to draw attention to a nosological unit called thrombotic microangiopathy (TMA). This syndrome represents a serious pathological condition characterized by microangiopathic haemolytic anemia (MAHA), thrombocytopenia and various organ dysfunction. Patients are most often presented with symptoms of the HELLP syndrome but if the clinical picture is not restituted within 48-72 hours after delivery, other TMAs should be considered.