Publications by authors named "A Toledano"
Background/objectives: Obesity, type 2 diabetes (T2D), and Alzheimer's disease (AD) are pathologies that affect millions of people worldwide. They have no effective therapy and are difficult to prevent and control when they develop. It has been known for many years that these diseases have many pathogenic aspects in common.
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- The study aimed to compare patient preferences for administering pegfilgrastim, a medication used to prevent chemotherapy-induced neutropenia, via prefilled syringe versus pen device among cancer patients at the Rafael Institute in France.
- In the trial involving 150 patients, results showed a significant preference for the pen device, with participants reporting lower pain levels and more positive emotions compared to the syringe, although satisfaction with nursing care was higher with the syringe.
- Overall, the findings highlighted a stronger preference for using the pen device for administration, which can help shape clinical practices and enhance patient-centered care.
A detailed assessment of a low energy demand, 1.5 C compatible pathway is provided for Europe from a bottom-up, country scale modelling perspective. The level of detail enables a clear representation of the potential of sufficiency measures.
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- Bartonella henselae is the bacteria behind cat scratch disease (CSD), which usually causes swollen lymph nodes but can sometimes lead to serious complications; this study aimed to analyze differences in clinical features between systemic and localized cases in children.
- The study reviewed medical records from a pediatric hospital in Buenos Aires, identifying 197 CSD patients, predominantly aged 8 years, with common symptoms being fever and lymphadenopathy; systemic involvement occurred in 34.5% of cases, often presenting as abscesses in organs like the spleen and liver.
- Findings indicated that patients with systemic diseases exhibited higher rates of fever and elevated C-reactive protein levels; nearly all patients received antibiotic
Background: Humoral immune response against the pre-fusion (pre-F) conformation of respiratory syncytial virus (RSV) F protein has been proposed to play a protective role against infection. An RSV pre-F maternal vaccine has been recently approved in several countries to protect young infants against RSV. We aimed to assess serum IgG titers against the pre-F and post-F conformations of RSV F protein and their association with life-threatening RSV disease (LTD) in previously healthy infants.
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