Publications by authors named "A Toivola"
Article Synopsis
- The TWINGEN study aims to identify individuals at high risk for Alzheimer's disease (AD) by assessing various cognitive and health-related factors through an observational clinical recall and biomarker analysis.
- The study involves around 800 participants, gathering data through blood samples, questionnaires, and wearable technology for lifestyle metrics, while also including a smaller group for in-person assessments.
- All data collected will be integrated with existing Finnish biobank records and utilized for further research, following ethical guidelines set by relevant authorities.
Introduction: A better understanding of the earliest stages of Alzheimer's disease (AD) could expedite the development or administration of treatments. Large population biobanks hold the promise to identify individuals at an elevated risk of AD and related dementias based on health registry information. Here, we establish the protocol for an observational clinical recall and biomarker study called TWINGEN with the aim to identify individuals at high risk of AD by assessing cognition, health and AD-related biomarkers.
View Article and Find Full Text PDFBackground: The results of a recent meta-analysis aroused concern about an increased risk of death associated with the use of paclitaxel-coated angioplasty balloons and stents in lower-limb endovascular interventions for symptomatic peripheral artery disease.
Methods: We conducted an unplanned interim analysis of data from a multicenter, randomized, open-label, registry-based clinical trial. At the time of the analysis, 2289 patients had been randomly assigned to treatment with drug-coated devices (the drug-coated-device group, 1149 patients) or treatment with uncoated devices (the uncoated-device group, 1140 patients).
Article Synopsis
- EndoVascular and Hybrid Trauma Management (EVTM) has been introduced for severe pelvic ring injuries, employing techniques like Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) to manage hemorrhage, though data on its effectiveness is limited.
- A study of 72 trauma patients with severe pelvic injuries found that most had blunt traumas, with traffic accidents being the most common cause, and REBOA was primarily used in the highest zone of aortic occlusion (zone 1).
- The overall mortality rate was noted to be 54.2%, with early mortality at 44.4%, influenced by various factors such as pH levels and blood pressure, although these
Background: Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) may improve Systolic Blood Pressure (SBP) in hypovolemic shock. It has, however, not been studied in patients with impending traumatic cardiac arrest (ITCA). We aimed to study the feasibility and clinical outcome of REBOA in patients with ITCA using data from the ABOTrauma Registry.
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