Publications by authors named "A Togari"
The ganglioside GD1a has been reported to promote the differentiation of mesenchymal stem cells to osteoblasts in cell culture systems. However, the involvement of gangliosides, including GD1a, in bone formation in vivo remains unknown; therefore, we herein investigated their roles in GM2/GD2 synthase-knockout (GM2/GD2S KO) mice without GD1a. The femoral cancellous bone mass was analyzed using three-dimensional micro-computed tomography.
View Article and Find Full Text PDFBackground/aim: Glycosphingolipids are known to be involved in bone metabolism. However, their roles and regulatory mechanisms in osteoblast proliferation are largely unknown. In this study, we examined the effects of inhibitors of glucosylceramide synthase (GCS), which is responsible for the generation of all glycosphingolipids, on osteoblast proliferation.
View Article and Find Full Text PDFObjectives: Orthodontic tooth movement (OTM) increases sympathetic and sensory neurological markers in periodontal tissue. However, the relationship between the sympathetic and sensory nervous systems during OTM remains unclear. Therefore, the present study investigated the relationship between the sympathetic and sensory nervous systems activated by OTM using pharmacological methods.
View Article and Find Full Text PDFIncrease of sympathetic activity has been known to exacerbate osteoporosis through promotion of bone resorption. However, it is largely unknown about involvement of sympathetic activity in exacerbation of periodontitis. In this study, we investigated whether α-adrenergic receptor (α-AR) agonist guanabenz which decreases sympathetic activity, attenuates alveolar bone resorption in rats having high sympathetic activity with periodontitis.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the effects of salubrinal, a synthetic compound that reduces endoplasmic reticulum (ER) stress, on periodontitis in a mouse model.
- Researchers used advanced imaging and staining techniques to assess changes in alveolar bone and attachment, along with measuring specific cell types involved in bone resorption and formation.
- Results showed that salubrinal effectively prevented bone loss associated with periodontitis and reduced inflammation, suggesting it could be a promising new treatment option for the disease.