Publications by authors named "A Toft"
Background: Maternal priming with bacille Calmette-Guérin (BCG) has been associated with reduced mortality in male offspring. We investigated this association in a cohort of healthy BCG-vaccinated neonates.
Methods: This observational study within a randomized controlled trial comparing different BCG strains was conducted in Guinea-Bissau from 2017 to 2020.
Introduction: Increasing evidence implicates proteostatic dysfunction as an early event in the development of frontotemporal dementia (FTD). This study aimed to explore potential cerebrospinal fluid (CSF) biomarkers associated with the proteolytic systems in genetic FTD caused by mutation.
Methods: Combining solid-phase extraction and parallel reaction monitoring mass spectrometry, a panel of 47 peptides derived from 20 proteins was analyzed in CSF from 31 members of the Danish -FTD family.
Article Synopsis
- The study investigated treatment outcomes for multidrug-resistant (MDR) and rifampicin-resistant tuberculosis (TB) in Central and West Africa, due to a lack of available data in these regions.
- Fourteen studies involving 4,268 individuals were analyzed, revealing a pooled treatment success rate of 80.8% in Central Africa and 69.2% in West Africa, which is higher than the WHO's global estimate of 59%.
- The findings suggest that shorter treatment regimens and standardized conditions may have led to improved outcomes, though the limited literature indicates a need for more comprehensive resources in these areas.
Free online tools for bacterial genome analyses are available for local infection surveillance at hospitals. The tools do not require bioinformatic expertise and provide rapid actionable results. Within half a year carbapenemase producing was reported in clinical samples from three patients who had been hospitalized at the same ward.
View Article and Find Full Text PDFOver a time period of 18 months an sequence type (ST) 90, harboring a carbapenemase gene, was isolated from seven patients at Odense University Hospital, Denmark. The patients were all from the same department, but there was no apparent direct epidemiological link. Whole genome sequencing (WGS) was performed on all clinical isolates as well as on a number of environmental samples including two ST90 isolates carrying the gene, which were isolated in samples from two shower drains at the department.
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