This paper proposes a novel targeted blend of machine learning (ML) based approaches for controlling wastewater treatment plant (WWTP) operation by predicting distributions of key effluent parameters of a biological nutrient removal (BNR) process. Two years of data were collected from Plajyolu wastewater treatment plant in Kocaeli, Türkiye and the effluent parameters were predicted using six machine learning algorithms to compare their performances. Based on mean absolute percentage error (MAPE) metric only, support vector regression machine (SVRM) with linear kernel method showed a good agreement for COD and BOD, with the MAPE values of about 9% and 0.
View Article and Find Full Text PDFRegul Toxicol Pharmacol
February 2024
Due to significant dietary supplement use in the US, product manufacturers must understand the importance of implementing a robust approach to establishing safety for all ingredients, including dietary ingredients, components, and finished dietary supplement products. Different regulatory pathways exist by which the safety of dietary ingredients can be established, and thus allowed to be marketed in a dietary supplement. For individual dietary ingredients, safety information may come from a variety of sources including history of safe use, presence of the ingredient in foods, and/or non-clinical and clinical data.
View Article and Find Full Text PDFThe objective of the present investigation was to prepare and optimize lyophilized mixed micelles (Lyp-EXE-MMs) of exemestane (EXE) with improved solubility, bioavailability, in vivo anticancer activity, and physical stability, by using various cryoprotectants. The prepared lyophilized mixed micelles were characterized by various techniques, including dynamic light scattering, zeta potential, powdered X-ray diffraction, differential scanning calorimetry (DSC), nuclear magnetic resonance ( H NMR), transmission electron microscopy (TEM), and so on. Thereafter, the lyophilized micelles were evaluated for ex vivo permeation, in vitro drug release and gene/protein expression (RT-PCR and Western blot analysis) in MCF-7 breast cancer cells.
View Article and Find Full Text PDFLateral reinforcement has a significant impact on the strength and ductility of concrete. Extra confinement is provided in this project by carbon fiber reinforced polymer (CFRP) sheets wrapped around the outside of reinforced concrete (RC) beams. To determine the failure criteria and maximum load-carrying capacity of beams, numerous specimens were cast and tested in a flexural testing machine.
View Article and Find Full Text PDFThe maternally inherited endosymbiont, , is known to alter the reproductive biology of its arthropod hosts for its own benefit and can induce both positive and negative fitness effects in many hosts. Here, we describe the effects of the maintenance of two distinct infections, one each from supergroups A and B, on the parasitoid host . We compare the effect of infections on various traits between the uninfected, single A-infected, single B-infected, and double-infected lines with their cured versions.
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