Biosimilar Use Among 38 ASCO PracticeNET Practices, 2019-2021.

Purpose: Biosimilars offer increased patient choice and potential cost-savings, compared with originator biologics. We studied 3 years of prescribed biologics among US physician practices to determine the relationship of practice type and payment source to oncology biosimilar use.

Methods: We acquired biologic utilization data from 38 practices participating in PracticeNET.

On-Board Imager-based MammoSite treatment verification.

Contemporary radiation oncology departments are often lacking a conventional simulator due to common use of virtual simulation and recent implementation of image guided radiation therapy. A protocol based on MammoSite method was developed using CT based planning, a Source Position Simulator (SPS) with a Simulator Wire and a linear accelerator based On-Board Imager (OBI) for daily verification. After MammoSite balloon implantation, the patient undergoes a CT study.

Effective palliative radiation therapy in advanced and recurrent ovarian carcinoma.

Purpose: To retrospectively review our experience using radiation therapy as a palliative treatment in ovarian carcinoma.

Methods And Materials: Eighty patients who received radiation therapy for ovarian carcinoma between 1983 and 1998 were reviewed. The indications for radiation therapy, radiation therapy techniques, details, tolerance, and response were recorded.

A critical evaluation of the planning target volume for 3-D conformal radiotherapy of prostate cancer.

Purpose: To determine an adequate planning target volume (PTV) margin for three-dimensional conformal radiotherapy (3D CRT) of prostate cancer, the uncertainties in the internal positions of the prostate and seminal vesicles (SV) and in the treatment setups were measured.

Methods And Materials: Weekly computed tomography (CT) scans of the pelvis (n=51) and daily electronic portal images (n=1630) were reviewed for eight patients who received seven-field 3D CRT for prostate cancer. The CT scans were registered in three dimensions to the original planning CT scan using commercially available software to measure the center-of volume (COV) motion of the prostate and SV.

The incidence of breast cancer following mantle field radiation therapy as a function of dose and technique.

Background: There is an increased incidence of breast cancer following mantle field radiation therapy for Hodgkin's disease (HD). We reviewed the experience at the Mallinckrodt Institute of Radiology (MIR) for radiation factors related to the development of breast cancer after mantle field radiation therapy for HD.

Methods: The radiation therapy records of 152 women treated with mantle field irradiation for HD at MIR between 1966-1985 were reviewed for the development of breast cancer and treatment-related factors.