Publications by authors named "A Theron"
Background: Although heritability of venous thromboembolism (VTE) is high, the thrombophilia screening appears to be positive only in a minority of VTE patients. Adding rare variants screening to identify VTE missing heritability still requires further assessment.
Objectives: We report the results of a panel strategy after 3 years of application.
Acetylcholinesterase inhibitors (AChEIs) remain the first-line treatment for Alzheimer's disease. However, these drugs are largely symptomatic and often associated with adverse effects. This study aimed to evaluate novel pharmacophores for their in vitro AChEI activity, blood-brain barrier (BBB) permeability, and cytotoxic potential, hypothesizing that a combination of AChEIs could enhance symptom management while minimizing toxicity.
View Article and Find Full Text PDFArticle Synopsis
- The first nuclear genome assembly and complete mitochondrial genome (mitogenome) for Hylesia metabus, a species of moth, has been presented, with the nuclear genome being one of the largest for lepidopterans at 1,271 Mb.
- The nuclear genome is organized into 31 pseudo chromosomes with a high quality BUSCO score of 99.5%, and contains a significant amount of repetitive elements, primarily located in intergenic regions.
- The assembled genomes are available on the BIPAA website and will aid future studies in population and comparative genomics.
Here, we report the results of the prospective cohort study EORTC-CLG 58081 and compare them to the control arm of the randomized phase 3 trial EORTC-CLG 58951, on which treatment recommendations were built. In both studies, patients aged 1-18 years with negative acute lymphoblastic leukemia of the B-lineage (B-ALL) or T-lineage (T-ALL) were treated using a BFM backbone without cranial irradiation. Similarly to the control arm of 58951, prednisolone (PRED) 60 mg/m/day was used for induction therapy, but a few modifications were made.
View Article and Find Full Text PDF