Publications by authors named "A Theodorakis"
Advances in the Management of Heart Failure with Reduced Ejection Fraction; The Role of SGLT2is, ARNI, Myotropes, Vericiguat, and Anti-inflammatory Agents: A Mini-review.
Curr Pharm Des
January 2023
Heart failure with reduced ejection fraction (HFrEF) has been associated with poor prognosis, reduced quality of life, and increased healthcare expenditure. Despite tremendous advances in HFrEF management, reduced survival and a high rate of hospitalization remain unsolved issues. Furthermore, HFrEF morbidity and economic burden are estimated to increase in the following years; hence, new therapies are constantly emerging.
View Article and Find Full Text PDFObjective: Colchicine has been utilized safely in a variety of cardiovascular clinical conditions. Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19. GRECCO-19 will be a prospective, randomized, open-labeled, controlled study to assess the effects of colchicine in COVID-19 complications prevention.
View Article and Find Full Text PDFAssociation of post-cardioversion transcardiac concentration gradient of soluble tumor necrosis factor-related apoptosis-inducing ligand (sTRAIL) and inflammatory biomarkers to atrial fibrillation recurrence.
Clin Biochem
August 2013
Article Synopsis
- The study investigates the levels of soluble tumor necrosis factor-related apoptosis-inducing ligand (sTRAIL) and inflammation markers in patients with atrial fibrillation (AF) after cardioversion, focusing on their relationship to AF recurrence.
- Results show that while sTRAIL and C-reactive protein levels were similar in recurring and non-recurring patients, interleukin-6 (IL-6) was significantly higher in those who experienced recurrence.
- The findings indicate a notable sTRAIL concentration gradient related to AF recurrence, suggesting that high sTRAIL levels could provide a protective effect in the heart, which may inform future treatments aimed at AF.
MicroRNAs are small RNA molecules and constitute a relatively novel class of gene expression regulators, found in the great majority of eukaryotic cells. Their role in human physiology and pathology is actively being researched with new exciting discoveries continuously coming to the forefront. MicroRNAs play a crucial role in the biogenesis and function of the cardiovascular system and act as important regulators of various metabolic and signaling pathways in cardiovascular disease.
View Article and Find Full Text PDFObjectives: The purpose of the present study was to test the potential of colchicine, an agent with potent anti-inflammatory action, to reduce atrial fibrillation (AF) recurrence after pulmonary vein isolation in patients with paroxysmal AF.
Background: Proinflammatory processes induced by AF ablation therapy have been implicated in postablation arrhythmia recurrence.
Methods: Patients with paroxysmal AF who received radiofrequency ablation treatment were randomized to a 3-month course of colchicine 0.