Publications by authors named "A Thalamuthu"
Beneficial associations between higher fruit and vegetable intakes and risk of depression appear to exist but few studies have focused on adults aged 45 + years and the potential that associations are due to residual confounding has not been tested. This longitudinal study of twins (n = 3483, age 45-90 years) from Australia, Denmark, Sweden and USA, assessed the associations between baseline fruit/vegetable intake and depressive symptoms over 5-11 years using linear mixed effects models. Intakes from food frequency questionnaires were trichotomized.
View Article and Find Full Text PDFIntroduction: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a rare genetic condition with a broad phenotypic presentation. This study aims to establish the first Australian cohort of individuals affected by CADASIL (AusCADASIL) and examine its clinical features and longitudinal course, and to investigate neuroimaging and blood biomarkers to assist in early diagnosis and identify disease progression.
Methods: Participants will be recruited from six study centres across Australia for an observational study of CADASIL.
Article Synopsis
- Individual sensitivity to environmental exposures is influenced by genetics, showing that different genetic makeups can lead to varying reactions to the same environment.
- A large meta-analysis was conducted using data from nearly 22,000 monozygotic twins to explore genetic influences on seven psychiatric and neurodevelopmental traits.
- The study found 13 significant genetic associations related to factors like stress-reactivity, growth factors, and catecholamine uptake, highlighting the potential role of genetics in understanding environmental sensitivity.
Article Synopsis
- - The study explored how genetic variation and the environment affect gene expression in older adults, focusing on a community sample of 246 individuals (mostly female twins).
- - Researchers found that about 24% of the analyzed genes showed heritability in blood gene expression, with 5269 significant probes identified, particularly linked to immune response and aging.
- - Comparisons with other studies revealed that only a small fraction of heritable genes were common, underscoring the necessity of studying gene expression specifically in older populations.