Human monocytic myeloid-derived suppressor cells impair B-cell phenotype and function in vitro.

Myeloid-derived suppressor cells (MDSCs) are key regulators of immunity that initially have been defined by their ability to potently suppress T-cell responses. Recent studies collectively demonstrate that the suppressive activity of MDSCs is not limited to T cells, but rather affects a broad range of immune cell subsets. However, relatively few studies have assessed the impact of MDSCs on B cells, particularly in the human context.

Myeloid-derived suppressor cells modulate B-cell responses.

Myeloid-derived suppressor cells (MDSCs) are key regulators of adaptive immunity by suppressing T-cell functions. However, their potential action on or interaction with B cells remained poorly understood. Here we demonstrate that human polymorphonuclear MDSCs differentially modulate B-cell function by suppressing B-cell proliferation and antibody production.

[Peri- and postmenopausal changes--body awareness, sexuality, and self- image of the middle-aged and older woman].

Unlabelled: INTRODUCTION, METHODS: For the first time a study has been made, in a German urban population, of sexuality, body awareness and self-image of women between 50 and 82 years. A special anonymous questionnaire was designed by female gynaecologists and psychologists for this cross-sectional study in Munich. It focuses on body awareness, self imagery, sexual activity and psychological and physiological sexual feeling in their biographic context.

A three step protocol for the treatment of idiopathic subfertility.

650 couples with idiopathic subfertility (mean duration: 5.7 year, range 2-21 years) were treated during 2870 cycles by three assisted conception methods (each involving mild ovarian stimulation): I timed intercourse (TI), II intrauterine insemination (IUI). III in vitro fertilization/embryo transfer (IVF/ET).