Publications by authors named "A Tedgui"
Article Synopsis
- Chronic high cholesterol levels lead to systemic immune responses that accelerate atherosclerosis, but the impact of alternating high-fat diets (HFD) had not been well studied.
- Researchers used a mouse model to compare the effects of an alternating HFD versus a continuous HFD on atherosclerosis progression, finding that the alternating diet significantly worsened the condition.
- The study revealed that this worsening was linked to IL-1β production, which triggered inflammatory responses and increased neutrophil levels that contributed to plaque formation and exacerbated atherosclerosis, suggesting that targeting these pathways could reverse the effects.
Article Synopsis
- * Early intermittent feeding of mice on a high-cholesterol diet speeds up atherosclerosis by altering arterial macrophage behavior and gene expression associated with ASCVD.
- * The Young Finns Study links early cholesterol exposure to increased carotid atherosclerotic plaque in adulthood, emphasizing the need for better hyperlipidaemia management early in life to prevent ASCVD.
Article Synopsis
- * A high-fat diet (HFD) changes how Trp is processed in the body and can lead to inflammation, which might worsen heart problems.
- * This study shows that controlling Tryptophan metabolism could help reduce gut inflammation and heart disease, leading to new treatment options.
