Publications by authors named "A Tay"
Transfection of proteins, mRNA, and chimeric antigen receptor (CAR) transgenes into immune cells remains a critical bottleneck in cell manufacturing. Current methods, such as viruses and bulk electroporation, are hampered by low transfection efficiency, unintended transgene integration, and significant cell perturbation. The Nanostraw Electro-actuated Transfection (NExT) technology offers a solution by using high aspect-ratio nanostraws and localized electric fields to precisely deliver biomolecules into cells with minimal disruption.
View Article and Find Full Text PDFObjective: Frontotemporal dementia (FTD) sagging brain syndrome is a disabling condition. An underlying spinal Cerebrospinal fluid leak can be identified in only a minority of patients and the success rate of non-directed treatments is low. Some of these patients have a remote history of craniectomy/cranioplasty and we report a positive response to custom implant cranioplasty revision many years after their initial cranioplasty.
View Article and Find Full Text PDFWhole-Genome Analysis of Multidrug-Resistant Klebsiella pneumoniae Kp04 Reveals Distinctive Antimicrobial and Arsenic-Resistance Genomic Features: A Case Study from Bangladesh.
Curr Microbiol
November 2024
Article Synopsis
- Multidrug-resistant bacteria, especially ESBL-producing strains like Klebsiella pneumoniae, are a major global health threat, with this study focusing on Kp04, a clinical isolate from Bangladesh.
- The investigation revealed high antibiotic resistance, with five isolated K. pneumoniae strains being resistant to 14 out of 21 tested antibiotics while only being sensitive to three specific ones.
- Whole-genome sequencing of Kp04 identified 75 genes associated with ESBL, virulence, and multiple drug resistance, highlighting similarities in virulence and resistance among isolates from Dhaka and Chattogram, indicating possible transmission of these strains in the region.