Peak Procedural ACT Is Associated With All-Cause Mortality After Femoral Access PCI.

Background: A minimum threshold activated clotting time (ACT) to guide heparin dosing during percutaneous coronary intervention (PCI) is associated with lower ischemic complications. However, data are variable regarding the risk of high ACT levels. The aim of this study was to assess the impact of peak procedural ACT on complications and mortality for transfemoral and transradial access PCI.

Expanding first-line options for depression: Protocol of a pragmatic comparative effectiveness trial of yoga vs. behavioral activation (the COMPARE study).

Depression is a prevalent mental health condition in the United States and a significant cause of morbidity and mortality. The treatment guidelines for depression recommends either psychotherapy, such as behavioral activation (BA), or a second-generation antidepressant as a first-line treatment for adult patients with depression. However, many individuals with depression do not experience improvement from first-line treatments or choose not to engage in them due to stigma, cost, difficulty with access, and/or side effects.

Web-based pain coping skills training (PCST) for managing aromatase inhibitor-associated arthralgia in breast cancer survivors: Randomized controlled trial protocol.

Background: Aromatase inhibitors (AIs) are a cornerstone of adjuvant systemic therapy for postmenopausal patients with hormone-receptor positive (HR+) breast cancer. Although AIs decrease cancer recurrence rates and improve survival rates, approximately 50 % of patients experience arthralgia-persistent pain related to worse patient outcomes and poor AI adherence. Current medical interventions for AI-associated arthralgia have limited efficacy and side effects that restrict their use among older patients.

Quantum Sensing of Spin Dynamics Using Boron-Vacancy Centers in Hexagonal Boron Nitride.

Spin defects embedded in solid-state systems are appealing for quantum sensing of materials and for quantum science and engineering. The spin-sensitive photoluminescence of optically active spin defects in Van der Waals based materials, such as the boron-vacancy (V_{B}^{-}) center in hexagonal boron nitride, enables its application as a quantum sensor to detect weak, spatially localized magnetic static and dynamic fields. However, the utility of V_{B}^{-} centers to probe spin dynamics in magnetic systems has yet to be demonstrated; this is essential to establish the V_{B}^{-} as a modular sensing platform that can be seamlessly integrated with emergent quantum materials to probe a wide range of static and dynamic phenomena.