Publications by authors named "A Talebian Yazdi"

Background: Mismatch between osteochondral allograft (OCA) donor and recipient sex has been shown to negatively affect outcomes. This study accounts for additional donor variables and clinically relevant outcomes.

Purpose: To evaluate whether donor sex, age, donor-recipient sex mismatch, and duration of graft storage affect clinical outcomes and failure rates after knee OCA transplantation.

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A 34-year-old male patient presented with a clinical picture of multilocular subcutaneous skin nodules in addition to marked lymphadenopathy and general physical deterioration. A comprehensive diagnostic workup including serology, skin biopsy and imaging studies led to the initial diagnosis of human immunodeficiency virus (HIV) infection in AIDS stage with rare multilocular subcutaneous bacillary angiomatosis (BA) caused by Bartonella henselae. BA describes a process of neovascularisation of the skin or of internal organs (particularly the liver and spleen) and was first described in HIV-positive patients by Stoler et al.

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Article Synopsis
  • The study focuses on the NLRP1 inflammasome, which is crucial for skin immune response, and aims to evaluate its activation in different keratinocyte cell lines.
  • Researchers compared NLRP1 activation, expression, and cell death in primary keratinocytes and immortalized cell lines (HaCaT, HaSKpw, SVTERT) after UVB irradiation or treatment with talabostat.
  • Findings indicated that primary keratinocytes showed the highest NLRP1 expression and detectable inflammasome activation, suggesting that they are the preferred model for studying inflammasome activation over immortalized keratinocyte cell lines.
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Article Synopsis
  • - The study aimed to measure the biomechanical stability of two fixation methods (suture button and suture tape cerclage) for anterior glenoid bone grafts, comparing hand tensioning to device tensioning.
  • - Researchers tested artificial bone blocks and recorded how much displacement occurred under various forces while using a cyclic loading protocol.
  • - Results showed that device tensioning provided significantly better stability than hand tensioning for both methods, particularly at forces over 100 N, with suture buttons performing better than suture tape at higher loads.
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Target class-focused drug discovery has a strong track record in pharmaceutical research, yet public domain data indicate that many members of protein families remain unliganded. Here we present a systematic approach to scale up the discovery and characterization of small molecule ligands for the WD40 repeat (WDR) protein family. We developed a comprehensive suite of protocols for protein production, crystallography, and biophysical, biochemical, and cellular assays.

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