Publications by authors named "A Takita"
Background: Off-label under- and overdosing of direct oral anticoagulants (DOACs) in patients with atrial fibrillation (AF) is not uncommon in real-world practice.
Objective: This study aimed to identify efficacy and safety of off-label DOACs dose after AF ablation.
Methods: The RYOUMA registry was a prospective multicenter study of Japanese patients who underwent AF ablation between 2017 and 2018.
Article Synopsis
- The All Nippon Atrial Fibrillation In the Elderly Registry studied over 30,000 elderly Japanese patients with non-valvular atrial fibrillation, focusing on outcomes based on age and type of oral anticoagulants (OACs).
- Results showed that the incidence of stroke, major bleeding, and intracranial hemorrhage increased significantly with age, but plateaued for those aged 90 and over.
- Direct OACs (DOACs) generally resulted in lower event rates compared to warfarin, particularly in patients aged 75-85 years, but had limited effectiveness in reducing major bleeding for patients aged 90 and older, suggesting very-low-dose DOACs might be beneficial for this older
Article Synopsis
- The study analyzed data from 1057 lung cancer surgery patients in Japan to understand the relationship between surgery and venous thromboembolism (VTE).
- It found that the surgery alone (SA) group had a lower incidence of VTE (0.2%) compared to the surgery plus chemotherapy (SC) group (3.3%); however, the SA group had a higher risk for cerebral ischemia (1.3% vs 0.9%).
- The research suggested that higher D-dimer levels (above 1.2 μg/ml) were linked to lymph node metastasis and indicated a greater risk of VTE and advanced cancer in patients.
Article Synopsis
- The study evaluates the relationship between frailty and clinical outcomes in elderly Japanese patients with non-valvular atrial fibrillation (NVAF) undergoing catheter ablation (CA) to determine the impact of CA on frailty and assess outcomes based on frailty status.
- A total of 213 elderly patients (average age of 72.8 years) were analyzed, revealing that 12.8% were frail, 53.7% pre-frail, and 33.5% robust, with frail patients experiencing more cardiovascular and bleeding events; however, most did not have AF recurrence after 3 or 6 months post-CA.
- The findings suggest that CA can improve factors related to frailty, indicating that