Publications by authors named "A Takehara"
Article Synopsis
- Meiotic sex chromosome inactivation (MSCI) is crucial for the proper development of sperm in mammals.
- The study highlights that La Ribonucleoprotein 7 (LARP7) is key for MSCI, promoting germ cell proliferation but displaying different activation stages throughout development.
- In mice lacking LARP7, spermatogenesis halts at the spermatocyte stage, with ongoing transcription of sex chromosome genes, indicating a failure in MSCI and abnormal epigenetic modifications in the XY body.
Background: The number of patients with heart failure (HF) is rapidly increasing as palliative care is being integrated into HF management and the need for a nursing workforce to meet these demands grows. To address this, we have developed a Web-based educational program on primary palliative care for HF among general registered nurses caring for patients with HF in Japan.
Objective: The aim of this study was to evaluate the program's effectiveness on nurse-reported palliative care practice, difficulty, and knowledge.
Sex-specific metabolic characteristics emerge in the mouse germ line after reaching the genital ridges around embryonic day 10.5, coinciding with sexual differentiation. However, the impact of such metabolic characteristics on germ cell development remains unclear.
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- A 79-year-old man with a recurrent inguinal bladder hernia underwent three unsuccessful surgeries before being treated with a totally extraperitoneal repair (TEP) technique.
- Preoperative imaging confirmed the hernia, which had previously been addressed via an anterior approach.
- The TEP method allowed safe reduction of the bladder hernia and effective repair using a specialized mesh, leading to an uneventful recovery and no recurrence after one year.