Publications by authors named "A Takaki"
Several reports revealed that oxidative stress was involved in the mouse model of nonsteroidal anti-inflammatory drug (NSAIDs)-induced small intestinal mucosal injuries. Thus, we aimed to investigate in the prospective clinical study, that the relevance of oxidative stress balance in small intestinal mucosal injury in NSAIDs users. We prospectively included 60 patients who had been taking NSAIDs continuously for more than 3 months and exhibited obscure gastrointestinal bleeding (number UMIN 000011775).
View Article and Find Full Text PDFThis report describes a 6-year-old boy who developed non-tuberculosis mycobacteria (NTM) catheter-related bloodstream infection (CRBSI) during treatment for B-cell precursor acute lymphoblastic leukemia. A Hickman catheter was inserted before starting treatment. He developed a fever during chemotherapy, and blood culture was drawn from the catheter.
View Article and Find Full Text PDFBackground And Aims: Methods for predicting therapeutic response to immune checkpoint inhibitors in cancer therapy are in high demand. In patients with advanced hepatocellular carcinoma (HCC), atezolizumab (anti-programmed cell death-ligand 1 [PD-L1]) and bevacizumab (anti-vascular endothelial growth factor) combination therapy (Atezo/Bev therapy) is a first-line treatment. However, no reliable biomarkers are currently available to predict its efficacy.
View Article and Find Full Text PDFArticle Synopsis
- Type 2 diabetes mellitus (T2DM) significantly increases the risk of developing hepatocellular carcinoma (HCC), which is typically diagnosed late in diabetes patients due to insufficient surveillance criteria.
- This study involved 330 T2DM patients with nonviral chronic liver disease diagnosed using imaging techniques, comparing clinical parameters between those with and without HCC.
- Key risk factors for HCC included age over 65, alcohol consumption, and specific laboratory results, highlighting the need for adapted HCC surveillance strategies tailored to both younger and older T2DM patients.
Evaluation of testing face-mask filter samples with LAMP shows high rates of detection in pulmonary TB.
Int J Tuberc Lung Dis
October 2024
Article Synopsis
- A study explored the use of bioaerosol detection of Mycobacterium tuberculosis (MTB) as a diagnostic tool for patients unable to provide sputum samples.
- Researchers developed a specialized mask with different types of filters to capture MTB particles from patients shortly after starting treatment.
- Results showed high sensitivity and perfect specificity for the filters, indicating that this method could be an effective alternative for diagnosing presumed tuberculosis in clinical settings.