Gliomatosis cerebri in children: A poor prognostic phenotype of diffuse gliomas with a distinct molecular profile.

Background: The term gliomatosis cerebri (GC), a radiology-defined highly infiltrating diffuse glioma, has been abandoned since molecular GC-associated features could not be established.

Methods: We conducted a multinational retrospective study of 104 children and adolescents with GC providing comprehensive clinical and (epi-)genetic characterization.

Results: Median overall survival (OS) was 15.

Comparison of expandable electrodes in percutaneous radiofrequency ablation of renal cell carcinoma.

Objective: To compare two different expandable electrodes in radiofrequency ablation of renal cell carcinoma.

Methods: Percutaneous ablation was performed at two centers using either an expandable 7F umbrella-shaped LeVeen probe (diameter 2-4 cm) and a 200-W generator (group A), or an expandable Starburst XL electrode with a 150-W generator (group B). From each center, eight patients with one tumor each were matched retrospectively with regard to tumor volume, which was 9.

Effect of growth hormone on exercise tolerance in children with cystic fibrosis.

Purpose: The effect of growth hormone (GH) treatment on exercise tolerance in children with cystic fibrosis was investigated.

Methods: 10 prepubertal children (mean +/- SD; age: 12.1 +/- 1.

[Effect of a new 10% hydroxyethyl starch solution HES/270/0.5 on blood coagulation, blood loss and hemodynamics in comparison with 3.5% PPL].

20 patients scheduled for total hip replacement were given 1,000 ml of a new preparation of 10% hydroxyethylstarch (HES) (MW 270,000: 0.5) preoperatively. They were compared to a group of 20 patients who received 1,000 ml of 3.

[Detection of bronchial hyperreactivity especially in exercise asthma using cold air hyperventilation provocation, free walking and acetylcholine].

In 92 children with different severity of bronchial asthma, a provocation by hyperventilation with cold air has been performed. Forty seven percent of the patients reacted with significant changes of RvD, of RoS, and of FEV1. All patients with negative response to cold air (53%) showed a significant increase of Ros after the inhalation of acetylcholine (threshold value: less than or equal to 0.