Publications by authors named "A T Zirh"
Objectives: We tested the hypothesis that Parkinson's disease (PA) alters the periodontitis-associated oral microbiome.
Method: Patients with periodontitis with Parkinson's disease (PA+P) and without PA (P) and systemically and periodontally healthy individuals (HC) were enrolled. Clinical, periodontal and neurological parameters were recorded.
Aim: The current study aimed to test the hypothesis that Parkinson's disease exacerbates periodontitis by altering its microbiome.
Materials And Methods: Clinical periodontal parameters were recorded. Subgingival samples from healthy controls, periodontitis patients (PD), and Parkinson's patients with periodontitis (PA+PD) were analyzed using the checkerboard DNA-DNA hybridization technique for targeting 40 bacterial species typically associated with periodontal disease and health.
Background: Parkinson's disease (PA) affects 1% of the global population above 60 years. PA pathogenesis involves severe neuroinflammation that impacts systemic and local inflammatory changes. We tested the hypothesis that PA is associated with periodontal tissue inflammation promoting a greater systemic inflammatory burden.
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- Dystonia is a movement disorder that affects quality of life, and while Botulinum Neurotoxin (BoNT) is a common treatment, it doesn't work for all patients; deep brain stimulation (DBS) has also been shown to benefit those with dystonia.
- A study of 67 dystonia patients treated with DBS over 7 years found significant improvements in symptoms, using scales like the Global Dystonia Severity (GDS) and Burke-Fahn-Marsden (BFMDRS) scores.
- The results showed average reductions in scores 5 to 7 years post-DBS, indicating DBS is an effective long-term treatment for various types of dystonia, despite not completely eliminating symptoms.
Deep brain stimulation (DBS) is still a highly effective treatment option that significantly improves motor function in advanced PD. Moreover, previous findings have shown that Olfactory dysfunction (OD) has been found in a majority of patients with Parkinson's Disease (PD). Despite this, the effect of DBS on the olfactory function is not fully understood.
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