All-electrical recursive generation and time-domain mode division multiplexing of Hermite-Gaussian pulses for optical, THz and RF links.

Space division multiplexing (SDM) with Hermite Gaussian (HG) modes, for instance, can significantly boost the transmission link capacity. However, SDM is not suitable in existing single mode fiber networks, and in long-distance wireless, microwave, THz or optical links, the far-field beam distribution may present a problem. Recently it has been demonstrated, that time domain HG modes can be employed to enhance the link capacity.

Animal-encoded nonribosomal pathway to bursatellin analogs.

The bursatellin-oxazinin family is a series of tyrosine-derived, nitrile-containing marine natural products from gastro-pod and bivalve molluscs. Although the first analogs were identified and associated with toxicity forty years ago, their biosynthetic origins were unknown. During an investigation of published mollusc genomes and transcriptomes, we serendipitously identified a putative bursatellin biosynthetic gene cluster (referred hereafter as the pathway).

Persistence of activated anti-mesothelin hYP218 chimeric antigen receptor T cells in the tumour is associated with efficacy in gastric and colorectal carcinomas.

Patients with advanced gastric and colorectal cancers have limited treatment options. Since mesothelin is highly expressed in these tumour types, we evaluated the therapeutic benefits of anti-mesothelin hYP218 CAR T cells alone, and in combination with anti-PD1 antibody, pembrolizumab. GEPIA analysis was performed using human gastric (n = 408) and colon cancer tumours (n = 275) in TCGA database, to evaluate mRNA expression of mesothelin, compared to normal tissues.

Diversity in clinical isolates of Ictalurid herpesvirus 1 (IcHV1) from U.S. farm-raised catfish and virulence assessment in channel and channel × blue catfish hybrids.

Ictalurid herpesvirus 1 (IcHV1) is the most significant viral agent in U.S. catfish aquaculture.