Publications by authors named "A T Titova"
Human butyrylcholinesterase (BChE) is an efficient bioscavenger of toxicants. Highly purified BChE was labelled with the near infrared fluorescent IRDye800CW. The goal was to determine the pharmacokinetics and fate of enzyme in mice.
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- Platelet homeostasis is vital for blood vessel stability and immune response, but the mechanisms behind the replenishment of their precursor cells (megakaryocytes) are not well understood.
- Researchers used intravital imaging to discover that plasmacytoid dendritic cells (pDCs) act as sensors in the bone marrow that detect dying megakaryocytes and stimulate the proliferation of their progenitor cells through the release of IFNα.
- The study highlights that while pDCs usually help fight viral infections, their activation by viruses like SARS-CoV-2 disrupts their monitoring function, leading to an overproduction of megakaryocytes.
The use of targeted drug delivery systems, including those based on selective absorption by certain receptors on the surface of the target cell, can lead to a decrease in the minimum effective dose and the accompanying toxicity of the drug, as well as an increase in therapeutic efficacy. A fullerene C conjugate (FA-PVP-C) with polyvinylpyrrolidone (PVP) as a biocompatible spacer and folic acid (FA) as a targeting ligand for tumor cells with increased expression of folate receptors (FR) was obtained. Using C NMR spectroscopy, FT-IR, UV-Vis spectrometry, fluorometry and thermal analysis, the formation of the conjugate was confirmed and the nature of the binding of its components was established.
View Article and Find Full Text PDFThe extraocular muscles (EOMs) possess unique characteristics that set them apart from other skeletal muscles. These muscles, responsible for eye movements, exhibit remarkable resistance to various muscular dystrophies and aging, presenting a significant contrast to the vulnerability of skeletal muscles to these conditions. In this review, we delve into the cellular and molecular underpinnings of the distinct properties of EOMs.
View Article and Find Full Text PDFBackground: Dysferlinopathy is a phenotypically heterogeneous group of hereditary diseases caused by mutations in the DYSF gene. Early contractures are considered rare, and rigid spine syndrome in dysferlinopathy has been previously reported only once.
Case Presentation: We describe a 23-year-old patient with Miyoshi myopathy with a rigid spine and multiple contractures, a rare phenotypic variant.