Publications by authors named "A T Thomaz"
This study aimed to evaluate the association between substance use during pregnancy (SUDP) and dental caries considering the Tooth Development Hypothesis and the Behavioral Hypothesis. This is a Brazilian cohort study conducted on 865 children (12-36 months). Exposure to SUDP was the latent variable and consisted of the use of alcohol, tobacco, and illicit drugs.
View Article and Find Full Text PDFCancer cells often display centrosome amplification, requiring the kinesin KIFC1/HSET for centrosome clustering to prevent multipolar spindles and cell death. In parallel siRNA screens of deubiquitinase enzymes, we identify OTUD6B as a positive regulator of KIFC1 expression that is required for centrosome clustering in triple-negative breast cancer (TNBC) cells. OTUD6B can localise to centrosomes and the mitotic spindle and interacts with KIFC1.
View Article and Find Full Text PDFArticle Synopsis
- - MEN2B is a genetic syndrome that leads to multiple health issues, including thyroid cancer, adrenal tumors, and distinctive physical traits like marfanoid habits and mucosal neuromas.
- - A 10-year-old boy had several health problems, including constipation, tongue lesions, slow growth, and neurological symptoms, prompting comprehensive medical assessments that eventually confirmed he had MEN2B.
- - The diagnosis of MEN2B typically requires the presence of medullary thyroid cancer, and additional mutations are common, highlighting the need for ongoing monitoring and genetic testing in affected individuals.
5-Fluorouracil (5-FU) is a chemotherapy drug widely used to treat a range of cancer types, despite the recurrence of adverse reactions. Therefore, information on its side effects when administered at a clinically recommended dose is relevant. On this basis, we examined the effects of the 5-FU clinical treatment on the integrity of the liver, kidneys, and lungs of rats.
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