Publications by authors named "A T Shende"
Engineering cells to sense and respond to environmental cues often focuses on maximizing gene regulation at the single-cell level. Inspired by population-level control mechanisms like the immune response, we demonstrate dynamic control and amplification of gene regulation in bacterial populations using programmable plasmid-mediated gene transfer. By regulating plasmid loss rate, transfer rate and fitness effects via Cas9 endonuclease, F conjugation machinery and antibiotic selection, we modulate the fraction of plasmid-carrying cells, serving as an amplification factor for single-cell-level regulation.
View Article and Find Full Text PDFPterygium in a Case of Bullous Pemphigoid - An Uncommon Association.
Indian Dermatol Online J
July 2024
Article Synopsis
- Pityriasis Rosea (PR) is a common skin condition with unclear causes, and the study aims to investigate its epidemiology, clinical features, and supporting diagnostic methods.
- The research involved 50 patients, analyzing their demographics, symptoms, and diagnostic findings through dermoscopy and histopathology, revealing that PR is more common in men (mean age 30.8 years) and often presents atypically in 40% of cases.
- Key findings included common dermoscopic features like red backgrounds and scale patterns, while histopathological analysis showed significant indicators such as spongiosis and lymphocytic infiltrate; however, the study's sample size was limited due to COVID-19 and lacked follow-up data.