Isolated Mouse Adult Cardiomyocytes Display Minimal Mitochondrial ATP Demand and Maximal Reliance on Glycolysis.

Mitochondrial maladaptation is a hallmark of heart failure, contributing to impaired energy production and contractile dysfunction. Understanding the bioenergetics of cardiomyocytes under healthy and pathological conditions is critical for characterizing mitochondrial maladaptation. While adult cardiomyocytes from rodents are a widely used model, recent studies have reported oligomycin insensitivity in these cells, a phenomenon often overlooked.

A study on the kinetic arrest of magnetic phases in nanostructured NdSrMnOthin films.

The NdSrMnO(NSMO) manganite system exhibits a phase transition from paramagnetic insulating (PMI) to ferromagnetic metallic (FMM) state around its Curie temperature= 270 K (bulk). The morphology-driven changes in the kinetically arrested magnetic phases in NSMO thin films with granular and crossed-nano-rod-type morphology are studied. The manganite thin films at low temperatures possess a magnetic glassy state arising from the coexistence of the high-temperature PMI and the low-temperature FMM phases.

A nudge over the relaxation plateau: effect of pH, particle concentration, and medium viscosity on the AC induction heating efficiency of biocompatible chitosan-coated FeOnanoparticles.

The effects of pH, MNP concentration, and medium viscosity on the magnetic fluid hyperthermia (MFH) properties of chitosan-coated superparamagnetic FeOnanoparticles (MNPs) are probed here. Due to the protonation of the amide groups, the MNPs are colloidally stable at lower pH (∼2), but form aggregates at higher pH (∼8). The increased aggregate size at higher pH causes the Brownian relaxation time () to increase, leading to a decrease in specific absorption rate (SAR).

Topological Data Analysis of Electroencephalogram Signals for Pediatric Obstructive Sleep Apnea.

Topological data analysis (TDA) is an emerging technique for biological signal processing. TDA leverages the invariant topological features of signals in a metric space for robust analysis of signals even in the presence of noise. In this paper, we leverage TDA on brain connectivity networks derived from electroencephalogram (EEG) signals to identify statistical differences between pediatric patients with obstructive sleep apnea (OSA) and pediatric patients without OSA.

Polymeric copper(I)-NHC complexes with bulky bidentate (N^C) ligands: synthesis and solid-state luminescence.

Starting from imidazolium chlorides bearing bulky nitrogen donors, a series of four complexes, mainly [Cu(C^N)Cl] coordination polymers were obtained directly as luminescent species by simple filtration from the aqueous reaction medium, highlighting a simple, eco-friendly, robust and reproducible synthetic procedure. Additionally, we have shown on the most efficient example that chloride could be exchanged very easily by other halides/pseudohalides (Br, I, NCS, N) allowing to slightly modulate the emitted colour while conserving the polymeric structure, except for azide for which a dimer was obtained. The combination of chemical analyses, of photoluminescence studies in the solid state including quantum yield measurement and X-ray diffraction on single crystals and as-synthesized microcrystalline powders highlighted that the polymeric luminescent species was indeed obtained directly by simple filtration and that no major alteration of the structure was observed upon recrystallisation.