Publications by authors named "A T Mach"
Article Synopsis
- Clozapine (CLO) is an effective antipsychotic but has varying blood levels, which can be influenced by individual factors like dose and personal characteristics.
- A study analyzed blood samples from 446 psychiatric patients to identify factors affecting CLO and its metabolite, norclozapine (NCLO), revealing that women, nonsmokers, and older patients tended to have higher drug concentrations.
- Despite taking recommended doses, only 37% of patients achieved therapeutic CLO levels, indicating that using CLO doesn't always ensure effective dosing, with a notable risk of toxicity among women and nonsmokers.
Background: Some new mothers have been shown to suffer from anxiety and depression associated with insomnia during the postpartum period. Our study assessed the impact of demographic, psychopathological, and biochemical factors on the incidence of depression in women during the early postpartum period.
Methods: A total of 119 women were evaluated at 24-48 h postpartum with the following psychometric scales: Hamilton Depression Rating Scale (HDRS), Edinburgh Postnatal Depression Scale (EPDS), Hamilton Anxiety Rating Scale (HARS) and Athens Insomnia Scale (AIS).
Introduction: Despite clear, relatively easy-to-use guidance, many clinicians find the preoperative management of direct oral anticoagulants (DOACs) challenging. Inappropriate management can delay procedures and lead to haemorrhagic or thromboembolic complications. We aimed to describe preoperative management practices regarding DOACs in a tertiary hospital and clinicians' adherence to in-house recommendations.
View Article and Find Full Text PDFThe aim of the study was to evaluate factors that may contribute to the persistence of positive, negative and other psychopathological symptoms of schizophrenia. All patients were treated in general psychiatric wards between January 2006 and December 2017. The initial study sample comprised of the medical reports of 600 patients.
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- Population genetic screening for cancer has sparked debates over costs and ethical concerns, with varying standards across countries focusing primarily on those with a personal or family cancer history.
- In a study involving 1076 Polish individuals, a broad analysis of genetic variants uncovered 19,551 rare variants in genes linked to cancer, with a notably low frequency of pathogenic variants like those in BRCA1/BRCA2.
- The study highlights challenges in accurately assessing the pathogenicity of rare variants and suggests the need for further research to improve understanding of variant frequency and implications for population-based whole genome screening.