Publications by authors named "A T Lovering"
Maximal static dry, that is, on land, apneas (breath-holds) result in severe hypoxemia and hypercapnia and have easy-going and struggle phases. During the struggle phase, the respiratory muscles involuntarily contract against the closed glottis in increasing frequency and magnitude, that is, involuntary breathing movements (IBMs). IBMs during maximal static apnea have been suggested to fatigue respiratory muscles, but this has yet to be measured.
View Article and Find Full Text PDFMolecular grappling hooks are the tools of a sticky bacterial predator.
View Article and Find Full Text PDFPopulation pharmacokinetics/pharmacodynamics of minocycline plus rifampicin in patients with complicated skin and skin structure infections caused by MRSA.
Sonia Luque Pardos William Hope Antigone Kotsaki Shampa Das Evangelos J Giamarellos-Bourboulis Andrew M Lovering
J Antimicrob Chemother
December 2024
Article Synopsis
- - The study aimed to analyze how the antibiotics minocycline, rifampicin, and linezolid perform in treating infections caused by MRSA in a population setting, using pharmacokinetics and pharmacodynamics data.
- - Researchers collected samples during a Phase 4 trial, comparing the effectiveness of oral minocycline plus rifampicin against linezolid, finding minocycline plus rifampicin to be just as effective as linezolid.
- - Despite most patients meeting the drug concentration targets for effective treatment, the study concluded that the pharmacokinetic/pharmacodynamic measurements did not correlate with clinical outcomes, meaning the expected model did not predict how well patients would respond to the treatment.
Article Synopsis
- The study aimed to assess how a patent foramen ovale and fibroblast growth factor-21 affect core temperature changes in SCUBA divers, while also examining the impact of wetsuit thickness and body measurements on these temperature shifts.
- Involving 31 divers, the research found no significant effect of the patent foramen ovale on temperature responses during dives or on fibroblast growth factor-21 levels.
- Results indicated that the combination of wetsuit thickness and individual body characteristics, like body mass and surface area, plays a significant role in regulating core temperature during diving.