Context- and sex-dependent links between sire sexual success and offspring pathogen resistance.

Sexual selection has been proposed to promote genetic variants that improve resistance to pathogens (a variant of the "good genes" hypothesis). Two key mechanisms linking sexual success and pathogen resistance have been proposed: the "condition-dependent" scenario, where general health improves both sexual traits and pathogen resistance, and the "context-dependent" scenario, where resistance to specific pathogens benefits sexual success only in certain environments. Few studies distinguish between these two mechanisms.

Conjugated Polyelectrolyte-Based Sensor Arrays: from Sensing Mechanisms to Artificial Sensory System Conceptualization.

In the past decades, conjugated polyelectrolytes (CPEs) have become prominent in sensing applications due to their unique properties, including strong and tunable light absorption, high sensitivity, water solubility, and biocompatibility. Inspired by mammalian olfactory and gustatory systems, CPE-based sensor arrays have made significant strides in discriminating structurally similar analytes and complex mixtures for various applications. This review consolidates recent advancements in CPE-based sensor arrays, highlighting rational design, controllable fabrication, and effective data processing methods.

Targeted Degradation Technology Based on the Autophagy-Lysosomal Pathway: A Promising Strategy for Treating Preeclampsia.

In recent years, targeted protein degradation (TPD) strategies leveraging the autophagy-lysosomal pathway (ALP) have transcended the limitations of conventional drug molecules, emerging as a highly promising approach for selectively eliminating disease-related proteins via the cell's intrinsic degradation machinery. These TPD methods, such as autophagosome-tethering compounds (ATTEC), autophagy-targeting chimera (AUTAC), AUTOphagy-TArgeting chimera (AUTOTAC), and chaperone-mediated autophagy (CMA) targeting chimera, exhibit efficacy in degrading misfolded protein aggregates associated with neurodegenerative disorders. Moreover, the excessive accumulation of misfolded proteins or protein complexes in the placenta has been identified as a significant contributor to preeclampsia (PE).

Gut microbiome and plasma metabolome alterations in ileostomy and after closure of ileostomy.

Unlabelled: A temporary loop ileostomy is a routine procedure for protecting the anastomosis in patients undergoing radical resection of rectal cancer. Fecal diversion by a diverting ileostomy may induce microbiota dysbiosis in the defunctioned colon; however, data on temporal and spatial microbiome and metabolome changes in these patients are sparse. Thirty patients who underwent ileostomy closure were enrolled.