Publications by authors named "A T Khachatrian"
Objectives: Patent foramen ovale (PFO) closure is recommended for patients who experience a cryptogenic stroke attributable to PFO. Although few randomized control trials (RCTs) have captured long-term effectiveness of PFO closure, observational data has been abundant. This is the first systematic review of observational studies determining incidence of long-term adverse outcomes in adults who underwent transcatheter PFO closure, with comparisons to findings from RCTs.
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- - This study focuses on new ionic liquids derived from imidazolium and choline containing 5-fluorouracil, exploring their effects on the structure and binding behavior with bovine serum albumin (BSA) using techniques like circular dichroism (CD) and fluorescence quenching.
- - The research investigates how the length of alkyl chains in these ionic liquids impacts their interaction with BSA and their aggregation tendencies through dynamic light scattering (DLS).
- - Results reveal that longer alkyl chains do not enhance binding to BSA, but one specific compound showed selectivity against cancer cells that regular 5-fluorouracil lacks, suggesting potential benefits in cancer treatment.
In this work, we describe the synthesis, interactions with bovine serum albumin, and cytotoxicity of new ionic liquids based on 5-fluorouracil (API-ILs) with different cations (imidazolium, choline, isoquinolinium, guanidinium). The secondary and tertiary structure of BSA in solutions with different concentrations of API-ILs was monitored by the circular dichroism (CD) technique. The addition of API-ILs does not lead to structural changes in BSA.
View Article and Find Full Text PDFThe paper reports the results of investigation intermolecular interactions between alanine and sarcosine anhydride in organic solvents. The absorption frequencies of cyclic dipeptide in solvents were measured by IR spectroscopy. The effect of Van der Waals interactions and the hydrogen bonding of solvents on absorption frequencies of the C=O group of anhydrides was discussed.
View Article and Find Full Text PDFPurpose: This study was undertaken to investigate efficacy of apixaban in prevention of haemorrhagic complications during treatment of proximal thromboses of deep veins of the lower extremities using endovascular techniques.
Patients And Methods: We retrospectively studied the results of treating a total of 50 patients presenting with deep vein thromboses at late stages of the pathological process. The patients were subdivided into 2 statistically homogeneous groups.