Preconditioning with hydrogen peroxide (H2O2) or ischemia in H2O2-induced cardiac dysfunction.

The possible cardioprotective effects of preconditioning by ischaemia (IPC) or a low dose of H2O2 (HPC) prior to a high dose of H2O2 was investigated. Langendorff-perfused rat hearts (n = 10 in each group) were subjected to 10 min of 140 micromol/L H2O2 and 30 min recovery after either (1) control perfusion, (2) 20 micromol/L H2O2 for 10 min, recovery 10 min, or (3) 2 x 2 min global ischaemia and 5 min reperfusion. 140 micromol/L H2O2 increased left ventricular end-diastolic pressure from 0 to 68+/-8 mmHg in controls (mean+/-SEM), which was attenuated by IPC (46+/-9 mmHg, p<0.

Effect of proximal gastric vagotomy on the activity of hydrogen, potassium-stimulated ATPase in the gastric mucosa of patients with duodenal ulcer.

Objective: To find out if there was a correlation between hydrogen, potassium stimulated ATPase (H,K-ATPase) activity and gastric acid secretion in patients with duodenal ulcers after proximal gastric vagotomy.

Design: Retrospective study.

Setting: Regional referral center.

Effect of truncal vagotomy and pyloroplasty on rat gastric mucosal H,K-ATPase and HCO3-ATPase activities.

The effect of truncal vagotomy and pyloroplasty on rat gastric mucosal H,K-ATPase and HCO3-ATPase activities was studied 15 and 30 days past the operation. A significant decrease in gastric body mucosal H,K-ATPase activity occurred 15 days after vagotomy, compared with pyloroplasty (p < 0.05) and non-operated control rats (p < 0.

[Comparative characteristics of the distribution and various properties of Na,K-ATPase from human and rat gastric mucosa].

Subcellular fractions were isolated from homogenates of human and rat gastric mucosal membranes by means of differential centrifugation; the highest Na+, K(+)-ATPase activity was detected in microsomal fraction. The enzymatic activity was higher in human gastric mucosal membrane as compared with the rat tissue. Na+, K(+)-ATPase activity was inhibited by 0.