Development of Artificial Intelligence-Based Real-Time Automatic Fusion of Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasonography of the Prostate.

Objectives: To report the development of artificial intelligence (AI)-based software to allow for the autonomous fusion of transrectal ultrasound and multiparametric magnetic resonance images of the prostate to be used during transperineal prostate biopsies.

Materials And Methods: This study was approved by the Institutional Review Board (protocol ID3167CESC). The automatic software development for fusion biopsy involved three steps: 1) Developing an AI component to segment the prostate during ultrasound; 2) Developing the component to segment anatomical structures in magnetic resonance images using labeled datasets from the Cancer Imaging Archive and in-house scans; 3) Developing the fusion component to register segmented ultrasound and magnetic resonance images using a three-step process: pre-alignment, rigid alignment, and elastic fusion, validated by measuring the lesion distance between modalities.

Toward predicting silver ion binding in proteins.

The binding of metal ions in proteins is often crucial for their function and hence for life. Silver is known to possess antimicrobial properties, yet little is known about the exact molecular mechanism of action. Based on the silver binding tetrapeptide moieties HXXM, and MXXH found in the silver efflux pump protein SilE, we studied the influence of the individual amino acids X and X and found trends that may be important in general metal ion binding in proteins.

Tick-borne pathogens in ticks removed from humans in Northern Italy, 2018-2023.

The rising prevalence and transmission of tick-borne pathogens (TBPs) represent a significant public health issue all over the world, including in Italy. The region of Lombardy, in Northern Italy, is particularly endemic for TBPs. While evidence indicates a high exposure risk to infected ticks, there is a lack of data on ticks collected from humans.

Cytokines and chemokines modulate the growth of pituitary adenoma/neuroendocrine tumors: preliminary results of a monocenter prospective pilot study.

Introduction: Cytokine and chemokines have been recognized to be involved in the progression and prognosis of pituitary adenoma/neuroendocrine tumors (PAs/PitNETs), also known as pituitary adenomas. We aim to investigate the expression of cytokine and chemokine in PAs/PitNETs, and their association with PAs/PitNETs clinical and biological behavior.

Patients And Methods: A prospective and monocenter study was performed on 16 patients diagnosed for PAs/PitNETs.

A Tele-Coaching Pilot Study: An Innovative Approach to Enhance Motor Skills in Adolescents With Down Syndrome.

Background: Limited knowledge exists regarding the effectiveness of training programmes for individuals with Down syndrome, particularly innovative approaches like tele-coaching. Our pilot study aimed to improve strength and balance using tele-coaching sessions in children with Down syndrome.

Materials And Methods: We enrolled 18 children and adolescents (aged 9-17 years) with Down syndrome.