Publications by authors named "A T Ichiki"
Background: The two-drug regimen of dolutegravir/lamivudine (DTG/3TC) is currently an optional antiretroviral therapy (ART). Despite its reported advantages on body weight and lipid profile, the same effects have not yet been reported for Asian population.
Methods: We conducted a single-center retrospective study involving Japanese people living with HIV (PLWH).
MYD88 p.L265P mutation occurs in over 90% of Waldenström's macroglobulinemia (WM), which is characterized by lymphoplasmacytic lymphoma (LPL) with monoclonal IgM. WM requires careful diagnosis due to overlapping features with other B-cell malignancies.
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- Identifying cells infected by Epstein-Barr virus (EBV) is crucial for understanding the disease's development, creating treatment plans, and predicting patient outcomes.
- The study utilized the PrimeFlow™ RNA Assay Kit to detect EBV-encoded small RNAs (EBERs) in various patient groups, including those with chronic active EBV disease and other EBV-related disorders.
- Findings revealed that patients with chronic active EBV disease showed widespread infection in T and NK cells, while other disorders demonstrated a mix of infected cell types, indicating that EBV may affect multiple cell types beyond just B cells.
The maximum likelihood method is the best-known method for estimating the probabilities behind the data. However, the conventional method obtains the probability model closest to the empirical distribution, resulting in overfitting. Then regularization methods prevent the model from being excessively close to the wrong probability, but little is known systematically about their performance.
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