Publications by authors named "A T Hsieh"
Background: Noninfectious anterior uveitis shares genetic factors, including HLA-B27, with ankylosing spondylitis (AS). The aim of this study was to identify significant single nucleotide polymorphisms (SNPs) associated with noninfectious anterior uveitis in AS patients, which could help predict the risk of developing this condition and provide deeper insights into its genetic underpinnings.
Methods: A genome-wide association study (GWAS) was conducted utilizing the genomic data of 468 AS patients, including 90 with noninfectious anterior uveitis and 378 without it, from the Taiwan Precision Medicine Initiative.
Background: Temozolomide (TMZ) treatment has demonstrated, but variable, impact on glioma prognosis. This study examines associations of survival with DNA repair gene germline polymorphisms among glioma patients who did and did not have TMZ treatment. Identifying genetic markers which sensitize tumor cells to TMZ could personalize therapy and improve outcomes.
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- Gliomas are the most common malignant brain tumors, often leading to serious neurological issues and high mortality, yet they usually do not spread outside the brain, suggesting they depend on the brain's unique environment.* -
- This study used a special rabies virus tracing technique in a mouse model to identify neurons that connect with glioma cells, revealing various brain regions involved in glioma innervation.* -
- Molecular profiling showed that these connecting neurons (GINs) predominantly use glutamate and GABA neurotransmitters, and their electrophysiological properties differ from typical neurons, indicating a specific neural interaction that could influence glioma behavior.*
Overcoming resistance to therapy is a major challenge in castration-resistant prostate cancer (CRPC). Lineage plasticity towards a neuroendocrine phenotype enables CRPC to adapt and survive targeted therapies. However, the molecular mechanisms of epigenetic reprogramming during this process are still poorly understood.
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