Publications by authors named "A T Hara"
Idiopathic pulmonary fibrosis (IPF) is the most common type of fibrosis in lungs, characterized as a chronic and progressive interstitial lung disease involving pathological findings of fibrosis with a median survival of 3 years. Despite the knowledge accumulated regarding IPF from basic and clinical research, an effective medical therapy for the condition remains to be established. Thus, it is necessary for further research, including stem cell therapy, which will provide new insights into and expectations for IPF treatment.
View Article and Find Full Text PDFInflammation and a metabolic shift from oxidative metabolism to glycolysis are common in the ischemic heart, the latter partly controlled by pyruvate kinase (muscle, PKM). We previously identified alternative splicing promoting the PKM2 isoform after myocardial infarction (MI). We examined the role of PKM2 physiological upregulation after MI, modeled by ligation of the left anterior descending coronary artery, using global PKM2 knockout (PKM2) mice.
View Article and Find Full Text PDFObjectives: Daily-use fluoride products are first-line protection against enamel wear from dietary-acid exposure (DAE). This study aimed to understand effects of fluoride concentration, fluoride salt, product form and ingredients in daily-use products on remineralisation and demineralisation, via network meta-analysis (NMA) of 14 studies using one well-established in-situ model. Remineralisation (surface-microhardness recovery, SHMR) after treatment, and protection against subsequent demineralisation (acid-resistance ratio, ARR) were measured.
View Article and Find Full Text PDFPrcis: Trabeculectomy increases tissue blood flow superior and temporal in the optic nerve head. Improvement of tissue blood flow superior and temporal in the optic nerve could be an indicator of the effectiveness of glaucoma treatment.
Purpose: To investigate changes in tissue blood flow at the optic nerve head before and after trabeculectomy.
Article Synopsis
- Silver Diamine Fluoride (SDF) is an effective, non-invasive treatment for dental caries but causes tooth discoloration, which affects patient acceptance.
- This study investigates how Zinc can help reduce discoloration caused by SDF while preserving the physical properties of dentin, such as hardness and roughness.
- Results show that higher concentrations of Zinc significantly decreased SDF-induced discoloration without adversely affecting dentin properties, suggesting potential for better patient acceptance in cosmetic dental treatments.