Update on Pulmonary Toxicity Induced by New Breast Cancer Treatments.

In recent years, new anticancer drugs have been investigated and approved for the treatment of breast cancer based on improved survival outcomes. However, these new treatments have specific class-related side effects. Pulmonary toxicity has been identified as an adverse event of special interest with everolimus, and is becoming an increasingly significant clinical challenge with the recent approval of trastuzumab deruxtecan.

Effectiveness and Predictors of Long-Term Treatment Response to Tofacitinib in Rheumatoid Arthritis Cohort: General Analysis and Focus on High-Cardiovascular-Risk Subgroup-A Multicenter Study.

The treatment landscape for Rheumatoid Arthritis (RA) has evolved significantly with the introduction of Janus kinase inhibitors (JAKi), such as Tofacitinib (TOFA), which offer a new therapeutic option for patients who have failed or are intolerant to conventional synthetic disease-modifying antirheumatic drugs (csDMARDs). Safety concerns, particularly related to cardiovascular and cancer risks, prompted a need for additional investigation in real-world clinical settings. This study aimed to evaluate the long-term effectiveness and predictors of response to TOFA in two subpopulations of RA patients, categorized by differing cardiovascular risk profiles.

The 36-week preeclampsia risk by the Fetal Medicine Foundation algorithm is associated with fetal compromise following induction of labor.

Background: Previous studies demonstrated that placental dysfunction leads to intrapartum fetal distress, particularly when an abnormal pattern of angiogenic markers is demonstrated at 36 weeks of gestation. The prediction of intrapartum fetal compromise is particularly important in patients undergoing induction of labor because of different indications for delivery, as this can be a useful in optimizing the method and timing of induction of labor.

Objective: This study aimed to examine whether the risk of preeclampsia assessed using the Fetal Medicine Foundation algorithm (derived from a combination of maternal risk factors, mean arterial pressure, placental growth factor, and soluble fms-like tyrosine kinase-1) is associated with the risk of intrapartum fetal compromise requiring cesarean delivery in a population of patients with singleton pregnancies undergoing induction of labor for various indications.

Heuristic absorption calculation in bilayered media from a white Monte Carlo dataset.

Monte Carlo (MC) simulations can adequately describe photon migration in layered media; however, storing and querying the resulting dataset may be computationally prohibitive when detailed path data are needed for each photon trajectory. A heuristic approach that significantly reduces the stored information to the average path length traveled by the photons detected in each layer is proposed. Its accuracy is evaluated by comparing it with the exact time point spread function () for a bilayered medium.