Epidemiological and clinical characteristics of children and young adults with Glanzmann's thrombasthenia in upper Egypt: a multicenter cross-sectional study.

Background: Glanzmann's thrombasthenia (GT) is an inherited rare bleeding disorder characterized by a deficiency or functional defect in the platelet αIIbβ3 integrin. This impairs normal platelet aggregation and leads to prolonged and spontaneous mucocutaneous bleeds.

Objectives: To report disease characteristics of a GT cohort from five tertiary hospitals in Upper Egypt.

Individual Genomic Loci, Transcript Level and Serum Profile of Immune, Antioxidant and Hormonal Markers Associated with Sheep Arthritis.

Arthritis is a leading cause of economic loss in livestock farming including sheep. This study examined the changes in gene expression, antioxidants, pro-inflammatory cytokines, acute-phase proteins (APPs), hormonal assays and iron profiles linked to sheep arthritis, as well as the diagnostic utility of these markers. Blood samples were obtained from 30 apparently healthy rams and 30 rams with arthritis for gene expression and biochemical analyses.

Improving Foaming Properties and Quality of Pasteurized Milk Using Antimicrobial Agents from Wild .

Pasteurized milk foam has become a quality issue in some applications, such as cappuccino-style drinks, as it should be stable and high-capacity. The extended shelf life of pasteurized milk is also a challenge. Some factors affect the foam capacity and stability; among them, the increasing amount of free fatty acids in raw milk is critical.

Dietary Plant-Based Mixture Improves Feed Efficiency, Gross Profit, Physiological Performance, Gene Expression and Gut Health of Nile Tilapia ().

The goal of this study was to evaluate the effect of the supplemental plant-based blend Phyto AquaNity (PAN) on growth, profitability and health status of Nile tilapia () cultured in hapas. Juvenile fish of average weight 73 g were stocked in 2-m hapas in triplicates at a density of 20 fish m (40 fish hapa). Four extruded diets were formulated following isonitrogenous (30% CP), isoenergetic (17 MJ kg) standards, with incorporation levels of 0, 0.

Nicotinamide dual treatment enhances morula-to-blastocyst transition through binding to Zonula Occludens-1 protein.

Nicotinamide (NAM) is a widely utilized compound in cell culture systems, yet its role during the morula-to-blastocyst transition remains underexplored. This study investigates the effects of NAM supplementation during both in vitro maturation (IVM) of oocytes and late-stage embryo culture (IVC3; the morula stage) on blastocyst development, metabolic flux, mitochondrial bioenergetics, and pluripotency of cells. Bovine oocytes were subjected to dual NAM treatment during IVM and IVC3 and its impact was assessed through cleavage and blastocyst development rates, mitochondrial membrane potential (ΔΨm), and the expression of key metabolic and pluripotency markers using RT-qPCR and immunofluorescence.