Publications by authors named "A T DeMarco"
High-risk human papillomavirus E6 oncoprotein is a model system for the recognition and degradation of cellular p53 tumor suppressor protein. There remains a gap in the understanding of the ubiquitin transfer reaction, including placement of the E6AP catalytic HECT domain of the ligase concerning the p53 substrate and how E6 itself is protected from ubiquitination. We determined the cryoelectron microscopy (cryo-EM) structure of the E6AP/E6/p53 complex, related the structure to in vivo modeling of the tri-molecular complex, and identified structural interactions associated with activation of the ubiquitin ligase function.
View Article and Find Full Text PDFArticle Synopsis
- About one third of stroke survivors experience post-stroke depression, which negatively impacts their quality of life, especially in those with chronic left-hemisphere stroke and a history of aphasia.
- A study involving 92 stroke survivors and 70 controls used the Beck Depression Inventory-II to measure depression and various scales to assess stroke-related disabilities, revealing that stroke survivors had significantly higher depression scores.
- The analysis indicated that lower cognitive, social participation, and perceived recovery scores were strongly linked to higher depression levels, highlighting the complexity of factors influencing depression post-stroke.
Posttraumatic stress disorder (PTSD) is a psychiatric disorder with defining abnormalities in memory, and psychedelics may be promising candidates for the treatment of PTSD given their effects on multiple memory systems. Most PTSD and psychedelic research has investigated memory with fear conditioning and extinction. While fruitful, conditioning and extinction provide a limited model of the complexity of PTSD and phenomenology of psychedelics, thereby limiting the refinement of therapies.
View Article and Find Full Text PDFArticle Synopsis
- This study focuses on the use of antiseizure medications (ASMs) for patients experiencing acute symptomatic seizures and examines factors linked to ASM treatment and patient outcomes.
- Conducted at five US medical centers, it analyzed data from 1,172 hospitalized adults who underwent continuous electroencephalography after having seizures between July and September 2021.
- Results showed that 45% of patients received ASM treatment, with significant differences based on seizure type, and 31% were prescribed ASMs upon discharge, with several factors influencing these outcomes.
Research over the past several decades has revealed that non-linguistic cognitive impairments can appear alongside language deficits in individuals with aphasia. One vulnerable cognitive domain is executive function, an umbrella term for the higher-level cognitive processes that allow us to direct our behavior towards a goal. Studies in healthy adults reveal that executive function abilities are supported by inner speech, the ability to use language silently in one's head.
View Article and Find Full Text PDF