Publications by authors named "A T Ayodeji"
Unlabelled: Lead optimization is vital for turning hit compounds into therapeutic drugs. This study builds upon a prior in silico research, where the hit compounds had better binding affinity and stability compared to a reference drug. Using a genetic algorithm, 12,500 analogs of the top compounds from the prior study were generated.
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- * A review of studies from 2000 to February 2024 reveals that these conditions lead to significant memory and cognitive impairments in mothers and cognitive deficits in their children due to factors like placental issues and maternal stress.
- * The research calls for a better understanding of the causes and the development of early interventions to help improve cognitive health in affected mothers and children through a multidisciplinary approach.
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- Ovarian cancer is a leading cause of death among gynecologic cancers, and this paper investigates the use of mirvetuximab soravtansine, a targeted therapy for platinum-resistant ovarian cancer expressing folate receptor alpha (FRα).
- Four key studies involving 453 participants show that mirvetuximab soravtansine is effective in fighting tumors with a good safety profile, particularly beneficial for tumors with high FRα expression.
- While the treatment shows promise for enhancing therapy outcomes, further research is needed to address patient diversity, improve quality of life data, and understand long-term safety, as well as to identify more biomarkers for personalized treatment options.
Strain improvement via chemical mutagen could impart traits with better enzyme production or improved characteristics. The present study sought to investigate the physicochemical properties of pullulanase produced from the wild and the mutant. The pullulanases produced from the wild and the mutant (obtained via induction with ethyl methyl sulfonate) were purified in a-three step purification procedure and were also characterized.
View Article and Find Full Text PDFThe Nigerian healthcare industry is bedevilled with infrastructural dilapidations and a dysfunctional healthcare system. This study investigated the influence of healthcare professionals' well-being and quality of work-life (QoWL) on the quality of care (QoC) of patients in Nigeria. A multicentre cross-sectional study was conducted at four tertiary healthcare institutions in southwest, Nigeria.
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